Madonna sometimes feels her "head is going to explode" as she juggles work and her family.
The superstar raises four children Lourdes, 15, Rocco, 12, David, six, and Mercy, five. She admits that maintaining her hectic career while being a single parent is challenging at times.
"I'm not going to lie it's hard work having four kids and doing all the work I do," she told British newspaper The Sun. "[I feel like my] head is going to explode.
"Everybody has something to say about the way I live my life. At the end of the day I'm doing my best. If people don't like it, then that's really their problem.
"Sometimes I cope with it very well, sometimes it's a struggle."
Madonna is currently promoting her new album MDNA.
The 53-year-old star says the song I Don't Give A is her response to all the critics who have slammed her parenting.
"It's about the life of a single mother," she explained. "It's a challenge juggling everything multi-tasking is my middle name. I try to express that."
The song also appears to take a swipe at her ex-husband Guy Ritchie.
The lyrics include "I tried to be a good girl, I tried to be your wife", and "I was trying to be all you expected of me". She also raps about custody battles and pre-nups.
Madonna went on to speak about her work on W.E. The star directed the movie and although she enjoyed the experience, she felt emotional about returning to the recording studio for MDNA.
"I like the intimacy of a recording studio and song-writing," she added. "I'm using a different part of my brain when I work on music versus than when I'm directing a film.
"It was very different. I love doing both but it was nice to get to the simplicity of song-writing after three years of writing a script, directing, editing and talking about my film.
"To sit down and play my guitar and sing a song I almost cried."
Madonna went on to reveal that her teenage daughter Lourdes is constantly approached to record songs or appear in movies.
However, the star insists that for now Lourdes just wants to be a "normal kid" and focus on her school work.
"Yes, she's my background singer She has a very good voice. She's quite shy about it and won't admit it," she explained. "If she ever wants to work with me on any level I welcome it. But otherwise I leave her to her homework and school."